1 edition of Genotoxic effects of Glycidyl-Trimethyl-Ammonium chloride found in the catalog.
Genotoxic effects of Glycidyl-Trimethyl-Ammonium chloride
1987 by Institut d"Hygiene et d"Epidemiologie, Ministere de la Sante Publique et de l"Environnement in Bruxelles .
Written in English
|The Physical Object|
|Number of Pages||24|
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2 Toxic Effects and Modes of Action The described effects of the substance in man after occupational exposure to glycidyl trimethylammonium chloride solution or powder include dermatitis and sensitization. Possible risk of irreversible effects. Harmful: danger of serious damage to health by prolonged exposure if swallowed.
Harmful in contact with skin and if swallowed. Highly flammable. Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. POTENTIAL HEALTH EFFECTS.
ACUTE HEALTH EFFECTS SWALLOWEDFile Size: KB. Published in the series Occupational Toxicants, Vol. 4 () The article contains sections titled.
Glycidyltrimethylammonium chloride (GTMAC) is a cationizing agent commonly used for starch modification.
Application Glycidyltrimethylammonium chloride be used as a derivatizing agent to synthesize N-(2-hydroxypropyl)trim ethylammonium chitosan chloride (HTCC), a water-soluble chitosan derivative, by reacting with chitosan.
HTCC can form. Effect of Incubation Time A kinetic study was performed to evaluate the effect of incubation time on the recoveries of MMS and EMS As shown in Figurea period of 15 minutes is a robust incubation time for the derivatization of MMS and EMS with chloride ion Author: Heewon Lee.
Sigma-Aldrich offers a number of Glycidyltrimethylammonium chloride products. View information & documentation regarding Glycidyltrimethylammonium chloride, including CAS, MSDS & more. Ahmad SI () Genotoxic effects of mercuric chloride in the albino rats, rattus norvegicus. Research Journal of Animal, Veterinary and Fishery Sciences 2(7): Glycidyl Trimethyl Ammonium Chloride.
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effects in bacterial and mammalian cell systems and possibly carcinogenic effects in vivo; thus, these compounds have raised safety conc erns in recent times (Snodin, ; Teasdale et al., ).
Crude oil compounds are very toxic to aquatic organisms, especially water soluble fraction compounds; these compounds are responsible to provoke genotoxic, mutagenicity and carcinogenic effects (Torres-Bugarin et al.,Woodhead et al.,Maria et al., c; Gravato and Santos, ).
In the present study, the analyses conducted showed. material regardless of the mechanism by which the change is induced.” Genotoxic impurities have also been defined as an “impurity that has been demonstrated to be genotoxic in an appropriate genotoxicity test model, e.g., bacterial gene mutation (Ames) test”.
A potential genotoxic impurity (PGI) has been defined as an “Impurity that shows. On the other hand, no effect of lead exposure on the frequency of SCE was observed by Beek and Obe,Hartwig et al.,who evaluated the genotoxic effect of lead acetate in human leukocytes and in Chinese hamster V79 cells, respectively, and by Zelikoff et al.
(), who assessed the genotoxicity of lead sulphide and lead nitrate in. The genotoxins ethyl chloride (EtCl) and methyl chloride (MeCl) were generated during the preparation of the hydrochloride salts of two tertiary amines in the presence of ethanol and methanol, respectively.
In EtOH five batches of a tertiary amine hydrochloride were prepared on −18 kg scale using 37% aqueous HCl; residual EtCl was detected at less than 10 ppm in each batch. Cite this article as: Boran H, Ulutas G () Genotoxic effects and gene expression changes in larval zebrafish after exposure to ZnCl 2 and ZnO nanoparticles.
Genotoxic effects are important indicators of carcinogenicity. The International Agency for Research on Cancer has classified compounds of arsenic, chromium (VI), nickel and cadmium as carcinogenic to humans (IARC, ). Benzalkonium chloride (BAC) acts as a preservative in numerous nasal preparations.
Possible genotoxic and cytotoxic effects of BAC in human respiratory epithelial BEAS-2B cells should be investigated in vitro. Cell cultures were exposed for 2 h to BAC. Trimethylacetyl chloride 99% Synonym: Pivaloyl chloride, Trimethylacetyl chloride CAS Number Linear Formula (CH 3) 3 CCOCl.
Molecular Weight Beilstein/REAXYS Number EC Number MDL number MFCD. Cytotoxic effects of mercuric chloride were greater than mercurous chloride. sativum was more resistant than A. cepa (Patra and Sharma, ), possibly due to the presence of greater amount of heterochromatin in the former and to the lower amount of sulphur compounds with affinity for mercury in the latter.
Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specifil phophodiesterase type 5 (PDE5). Sildenafil enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5, which is responsible for the degradation of cGMP in the corpus cavernosum.
The possible genotoxic impurities of sildenafil were synthesized, i.e., sildenafil sulfonyl methyl ester. Cells were exposed to μg/ml and μg/ml concentration of arsenic and lead, respectively, for 6, 12, 24 and 48 h. The cytotoxic effects were measured by neutral red uptake assay, while the genotoxic effects were tested by comet assay.
The growth of cells decreased with increasing concentration and the duration of exposure to arsenic. Chlorine is a widely used disinfectant which prevents the spread of harmful pathogens when reusing wastewater, but harmful byproducts might be formed and cause adverse ecological and health effects.
In this study, the potential effects of chlorination on the genotoxicity of different biologically treated wastewater samples were investigated using the umu test. For the first time. No work has reported that this compound induces genotoxic or carcinogenic effects or that impacts reproduction and fertilization.
The effects of this class of compounds range from irritation upon local contact (skin, GI), to hypotension, development of acute renal failure with oliguria, and severe hypoxia and death [ 54 ]. The effects of CoNPs were compared with those induced by cobalt chloride (CoCl 2), as a model ion releasing agent, to determine the role of the nanosized shapes in the observed responses.
The obtained results indicate that ingested CoNPs translocate through the intestinal barrier of Drosophila larvae affecting hemolymph cells. Patrizia Guidi's 25 research works with citations and 3, reads, including: Suitability of a Cellulose-Based Nanomaterial for the Remediation of Heavy Metal Contaminated Freshwaters: A Case.
Associated Universities, Inc./Brookhaven National Laboratory Medical Department. Symposium on Genotoxic Effects of Airborne Agents (). Genotoxic effects of airborne agents. New York: Plenum Press, © (OCoLC) Material Type: Conference publication: Document Type: Book: All Authors / Contributors.
Recently, soluble forms of aluminum for human use or consumption have been determined to be potentially toxic due to their association with hepatic, neurological, hematological, neoplastic, and bone conditions. This study aims to assess the genotoxic effect of aluminum chloride on genomic instability associated with the onset of N-nitroso-N-methylurea (NMU)-induced breast cancer in Sprague.
The most marked effects of exposure in humans are central nervous system toxicity and impaired respiration. Degenerative changes occur in the brain and spinal cord, and lesions are also seen in the liver, kidneys, lung, heart, and gastrointestinal tract.
Similar toxic effects occurred in animal studies, as well as testicular and spleen lesions. Drug pre-treated series (T 1 –T 2). 1 drop of stock solution ( ml) of the homeopathic drug (both 30th and th potencies in separate series) was orally administered to mice with the aid of a pipette every 4 hr prior to the injection of CdCl respective times of beginning of drug feeding before injection were 6 hr, 12 hr, 24 hr, 48 hr, 72 hr and 96 hr to the sets of mice destined to.
Get this from a library. Genotoxic Effects of Airborne Agents. [Raymund R Tice; Daniel L Costa; Karen M Schaich] -- For at least 40 years there has been a great interest in the problems created by infectious airborne agents and other toxic sub stances transported. Search term: "glycidyl trimethylammonium chloride" Compare Products: Select up to 4 products.
*Please select more than one item to compare. 1 match found for glycidyl trimethylammonium chloride. Advanced Search | Structure Search. Glycidyltrimethylammonium chloride. Variations of pH value in aqueous GTAC solution during potentiometric titration with: a) M HCl, b) M CH 3 COOH.
( mL of acid was added every 30 s). For at least 40 years there has been a great interest in the problems created by infectious airborne agents and other toxic sub stances transported through the air. During the Second World War, this problem grew out of the very high incidence of upper respira tory infections appearing in new.
EPA//R/F TOXICOLOGICAL REVIEW. DICHLOROMETHANE (METHYLENE CHLORIDE) (CAS No. ) In Support of Summary Information on the. Cytotoxic and genotoxic effects of arsenic and lead on human adipose derived mesenchymal stem cells (AMSCs).
Stem Cells Regen. Med. 9: SHARIFI A.M. GHAZANFARI R. TEKIYEHMAROOF N. AND ASHARIFI M. Investigating the effect of lead acetate on rat bone marrow-derived mesenchymal stem cells toxicity: Role of apoptosis.
Toxicol. Mech. Meth. Genotoxic definition ata free online dictionary with pronunciation, synonyms and translation. Look it up now.
IUPAC Standard InChIKey: OKIZCWYLBDKLSU-UHFFFAOYSA-M CAS Registry Number: Chemical structure: This structure is also available as a 2d Mol file; Other names: TMAC; Methanaminium, N,N,N-trimethyl- chloride; Ammonium, tetramethyl- chloride; USAF AN-8 Permanent link for this species.
Use this link for bookmarking this species for future reference. Genotoxic Impurities The focus of this guideline is on DNA reactive substances which can be detected by Ames assay. Application of Threshold of Toxicological Concern (TTC) to control genotoxic impurities. Risk assessment for patients and healthy volunteers during clinical development.
Evaluation of genotoxicity of impurities using the. Stannous chloride (SnCl 2) and UVA induce DNA lesions through aim of this work was to study the toxicity induced by UVA preillumination, followed by SnCl 2 treatment. coli BER mutants were used to identify genes which could play a role in DNA lesion repair generated by these agents.
The survival assays showed (i) The nfo mutant was the most sensitive to SnCl 2; (ii) lethal. Genotoxic studies with reference to pollution biomonitoring is a recent approach and can be used for maintenance of crop productivity. Effect of the cadmium chloride in the pure germ line of broad bean (Vicia faba L.) were evaluated in relation to the chromosomal abnormalities and rate of cell grown in the nutrient medium for 48 hrs containing different concentrations of cadmium.
Thus, while these studies provide useful information towards understanding arsenic's mechanism, it is important to understand how arsenic affects normal human lung cells. Accordingly, we investigated the genotoxic effects of inorganic arsenic in normal primary human bronchial fibroblasts and epithelial cells.
The effects of magnesium carbonate on the cytotoxicity and genotoxicity induced by nickel subsulfide were examined with respect to the inhibition of cell proliferation, micronuclei formation, DNA-protein cross-link formation, and intranuclear nickel concentration. The generation of reactive oxygen by nickel chloride was also analyzed by.Lower concentrations of ETU can affect the morphology and function of cells in the ovarian follicles of mammals (Paro et al., ).
The effects of paraquat (1,1-dimethyl-4,4-chloride bipyridylium), which is a prototypical agricultural herbicide, have been described by Ranjbar et al. (). It promotes toxic effects mainly in the liver and kidney. In vitro studies carried out using OP have provided evidence that these pesticides could damage DNA in human sperm thus causing genotoxic effects .
Among widely used and toxic OPs in Sri Lanka, acephate (O,S-dimethyl acetylphosphoramidothioate) is an insecticide, used in agriculture and domestic purposes due to its wide spectrum insecticide.